Corneal transplants, also known as corneal grafts, are surgical procedures designed to replace a damaged or diseased cornea with healthy tissue from a donor. While many patients experience improved vision and quality of life after this surgery, there are instances where the transplant does not take. Understanding what happens in these cases can help patients prepare and make informed decisions.

When a corneal transplant doesn’t take, this typically means that the body has rejected the donor tissue or that the transplant has failed for other reasons. Symptoms of transplant rejection can vary but often include:

• Decreased vision or blurred vision
• Eye redness and irritation
• Increased sensitivity to light
• Swelling in the surrounding tissues

If you experience any of these symptoms after undergoing a corneal transplant, it is crucial to consult your ophthalmologist as soon as possible. Early detection of rejection or complications can be vital in salvaging the graft.

The most common cause of transplant failure is graft rejection. The immune system may incorrectly identify the transplanted tissue as a foreign object and attack it. Medications to suppress the immune response, such as corticosteroids, are often prescribed to prevent this rejection. However, some patients may still experience rejection despite following their medication regimen.

Aside from rejection, other factors can contribute to transplant failure, including:

• Infection: Post-surgical infections can jeopardize the success of the graft.
• Corneal edema: Swelling of the cornea can occur if the transplant does not integrate properly.
• Underlying conditions: Diseases such as keratoconus or Fuchs' dystrophy may impact the success rate of the transplant.

If a corneal transplant does not take, the options for patients may include:

• Medical treatment: Continued use of anti-rejection medications or additional therapies may help stabilize the situation.
• Further surgery: In some cases, a second transplant may be necessary if the first graft fails.
• Alternative treatments: Depending on the condition, other surgical options or corrective lenses may be available.

It’s critical for patients to follow their post-operative care plan, including attending all follow-up appointments and adhering to prescribed medications. Regular monitoring can help detect any issues early on and improve the overall outcome.

In summary, while a corneal transplant can significantly improve one’s vision, there is a risk that it may not take. Awareness of the signs of rejection and understanding the factors that contribute to transplant failure can empower patients. Always consult with an eye care professional for guidance tailored to your situation.